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76 Studies have shown that within various cell types, including vascular smooth muscle cells, endothelial cells, adipocytes, hepatocytes, pancreatic islet cells, and renal tubular cells, uric acid can activate NADPH oxidase, a crucial enzyme involved in the generation of reactive oxygen species

J Physiol 535(Pt 1):301311 [DOI] [PMC free article] [PubMed] [Google Scholar] 49.Simonson M, Boirie Y, Guillet C (2020) Protein, amino acids and obesity treatment

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Between-study heterogeneity was assessed using the Q statistic, (tau-squared), and I statistic